Vernetztes Wissen

Innerhalb der Gedächtnisinstitutionen Bibliothek, Museum und Archiv gibt es je eigene Beschreibungsmodelle der beherbergten Objekte und Materialien. Für eine genauere bibliographische Erschließung wurde im Bibliotheksbereich das von Benutzerbedürfnissen ausgehende, statische Modell "Functional Requirements for Bibliographic Records" (FRBR) geschaffen, dessen ungenauer "Werk"-Begriff ebenso thematisiert wird wie die schwer zu realisierende Übertragbarkeit des Modells auf Nicht-Buchmaterialien. Die Museumswelt orientiert die Darstellung ihrer Bestände am CIDOC Conceptual Reference Model (CRM), das sich hinsichtlich der Beschreibung heterogener Museumsobjekte, also Artefakten künstlerischer und intellektueller Gestaltung, als hilfreich erwiesen hat. In gegenseitigem Austausch zwischen IFLA und ICOM wurde FRBR mit CRM harmonisiert. Das Ergebnis, FRBROO (Objektorientiertes FRBR), zeigt seine Vorzüge zum einen in einer strengeren Interpretation der Entitäten der Gruppe 1 des FRBR-Modells und zum anderen in einer genaueren Abbildung von Prozessen bzw. Ereignissen. Beispiele zum Anwendungsbezug von FRBROO zeigen dessen Zugewinn für die wissenschaftliche Erschließung hand-, druck- und online-schriftlicher Quellen, Werken der Darstellenden Kunst, Landkarten und Musikalien innerhalb einer CRM-basierten Datenbank.Each of the three memory institutions library, museum and archive has developed his own conceptual model for their holdings of objects and materials. The static model "Functional Requirements for Bibliographic Records" (FRBR) was established for a more precise bibliographic indexing in libraries. But this model lacks a detailed concept of the entity "work" and is not that much useful for non-book materials. The CIDOC Conceptual Reference Model (CRM) is the central data model for museums; it is very appropriate for the heterogeneous mass of museum objects and artefacts which are all products of an artistic or intellectual creation. IFLA and ICOM harmonized FRBR with CRM in mutual exchange. The outcome, FRBROO (object-oriented FRBR), shows advantages in terms of a more strict interpretation of the group 1-entities of FRBR, and also in a closer illustration of processes and events. Examples of an applied approach of FRBROO show its gain in scientific indexing of manuscripts, prints, online publications, performing arts, maps, and musical works within a CRM-based data base

Innovative Planungskonzepte in der Flughafen-Logistik

Die Gepäckförderanlagen von Luftfahrt-Drehkreuzen wie Peking oder Dubai gehören mit etwa 100 km Förderstrecke und 10.000 Transporteinheiten heute zu den größten automatisierten Logistiksystemen. Die Professur für Technische Logistik der TU Dresden ist an ihrer Planung und Simulation beteiligt und entwickelt Werkzeuge für den Systementwurf. Der Beitrag stellt zuerst Gepäckförderanlagen und die Planungsaufgabe vor. Danach werden zwei innovative Konzepte für frühe Planungsstufen vorgestellt. Dabei wird das Anlagen-Layout in ein Knoten-Kanten-Modell überführt. So wird einerseits mit diskretisierten statistischen (Zeit-) Verteilungen das dynamische Anlagenverhalten schneller und ähnlich genau bewertet wie mit der Simulation. Andererseits werden statistische Maßzahlen aus der Theorie komplexer Netzwerke genutzt, um das Transportnetzwerk hinsichtlich Robustheit und Lastbalancierung zu optimieren.Baggage handling systems of air hubs like Beijing or Dubai contain about 100 km of conveyor lines and 10,000 transport units. Thus they belong to today’s largest automated logistics systems. The Chair for Logistics Engineering at TU Dresden is involved in their planning and simulation and develops system design tools. The paper first introduces into the field and the design targets. Than two innovative concepts for early planning stages are presented which derive a node-link-model from the system’s layout. Now, the system dynamic is evaluated by means of time-discrete statistic distributions more rapidly and as exactly as by simulations. Besides, statistic measures from complex network theory are used to optimise the transport with respect to robustness and load balancing

High interindividual variability in dose-dependent reduction in speed of movement after exposing C. elegans to shock waves

In blast-related mild traumatic brain injury (br-mTBI) little is known about the connections between initial trauma and expression of individual clinical symptoms. Partly due to limitations of current in vitro and in vivo models of br-mTBI, reliable prediction of individual short-and long-term symptoms based on known blast input has not yet been possible. Here we demonstrate a dose-dependent effect of shock wave exposure on C. elegans using shock waves that share physical characteristics with those hypothesized to induce br-mTBI in humans. Increased exposure to shock waves resulted in decreased mean speed of movement while increasing the proportion of worms rendered paralyzed. Recovery of these two behavioral symptoms was observed during increasing post-traumatic waiting periods. Although effects were observed on a population-wide basis, large interindividual variability was present between organisms exposed to the same highly controlled conditions. Reduction of cavitation by exposing worms to shock waves in polyvinyl alcohol resulted in reduced effect, implicating primary blast effects as damaging components in shock wave induced trauma. Growing worms on NGM agar plates led to the same general results in initial shock wave effect in a standard medium, namely dose-dependence and high interindividual variability, as raising worms in liquid cultures. Taken together, these data indicate that reliable prediction of individual clinical symptoms based on known blast input as well as drawing conclusions on blast input from individual clinical symptoms is not feasible in br-mTBI

Novel 3D light microscopic analysis of IUGR placentas points to a morphological correlate of compensated ischemic placental disease in humans

The villous tree of the human placenta is a complex three-dimensional (3D) structure with branches and nodes at the feto-maternal border in the key area of gas and nutrient exchange. Recently we introduced a novel, computer-assisted 3D light microscopic method that enables 3D topological analysis of branching patterns of the human placental villous tree. In the present study we applied this novel method to the 3D architecture of peripheral villous trees of placentas from patients with intrauterine growth retardation (IUGR placentas), a severe obstetric syndrome. We found that the mean branching angle of branches in terminal positions of the villous trees was significantly different statistically between IUGR placentas and clinically normal placentas. Furthermore, the mean tortuosity of branches of villous trees in directly preterminal positions was significantly different statistically between IUGR placentas and clinically normal placentas. We show that these differences can be interpreted as consequences of morphological adaptation of villous trees between IUGR placentas and clinically normal placentas, and may have important consequences for the understanding of the morphological correlates of the efficiency of the placental villous tree and their influence on fetal development

Radial extracorporeal shock wave treatment harms developing chicken embryos

Radial extracorporeal shock wave treatment (rESWT) has became one of the best investigated treatment modalities for cellulite, including the abdomen as a treatment site. Notably, pregnancy is considered a contraindication for rESWT, and concerns have been raised about possible harm to the embryo when a woman treated with rESWT for cellulite is not aware of her pregnancy. Here we tested the hypothesis that rESWT may cause serious physical harm to embryos. To this end, chicken embryos were exposed in ovo to various doses of radial shock waves on either day 3 or day 4 of development, resembling the developmental stage of four- to six-week-old human embryos. We found a dose-dependent increase in the number of embryos that died after radial shock wave exposure on either day 3 or day 4 of development. Among the embryos that survived the shock wave exposure a few showed severe congenital defects such as missing eyes. Evidently, our data cannot directly be used to draw conclusions about potential harm to the embryo of a pregnant woman treated for cellulite with rESWT. However, to avoid any risks we strongly recommend applying radial shock waves in the treatment of cellulite only if a pregnancy is ruled out

Radial extracorporeal shock wave treatment harms developing chicken embryos

Radial extracorporeal shock wave treatment (rESWT) has became one of the best investigated treatment modalities for cellulite, including the abdomen as a treatment site. Notably, pregnancy is considered a contraindication for rESWT, and concerns have been raised about possible harm to the embryo when a woman treated with rESWT for cellulite is not aware of her pregnancy. Here we tested the hypothesis that rESWT may cause serious physical harm to embryos. To this end, chicken embryos were exposed in ovo to various doses of radial shock waves on either day 3 or day 4 of development, resembling the developmental stage of four- to six-week-old human embryos. We found a dose-dependent increase in the number of embryos that died after radial shock wave exposure on either day 3 or day 4 of development. Among the embryos that survived the shock wave exposure a few showed severe congenital defects such as missing eyes. Evidently, our data cannot directly be used to draw conclusions about potential harm to the embryo of a pregnant woman treated for cellulite with rESWT. However, to avoid any risks we strongly recommend applying radial shock waves in the treatment of cellulite only if a pregnancy is ruled out

Факторы социально-экономической мобильности населения России

В данной статье говорится о факторах социально-экономической мобильности населения в современных условиях России, дается определение горизонтальной социальной мобильности и вертикальной социальной мобильности, рассматривается феномен социально-экономической мобильности в теориях социального неравенства